Sam Tsimikas: Uncovering a Modifiable Lp(a) Phenotype in Hypertriglyceridemia
Sam Tsimikas, Professor of Medicine at the University of California, San Diego, shared a post on X about a recent article by Lizhu Lin et al, published in JACC: Basic to Translational Science, adding:
“We have a new paper today that links Lp(a) with triglycerides in patients with moderate hypertriglyceridemia (TG 150-500).
Using our new methods we developed UC San Diego Cardiology.
Lp(a) becomes TG- and cholesterol-enriched.
ApoC-III inhibition reduced Lp(a)-TG and Lp(a)-C by approximately 60–70 percent without lowering Lp(a) particle number, revealing pharmacologically modifiable Lp(a) heterogeneity.
We now need to see how Lp(a)-C and Lp(a)-TG correlate with CV outcomes.”
Title: A Novel Triglyceride- and Cholesterol-Enriched Lipoprotein(a) Phenotype in Moderate Hypertriglyceridemia: Reversal by ApoC-III Inhibition
Authors: Lizhu Lin, Maiah N. Brush, C. Bradley Nelson, Veronica J. Alexander, Shuting Xia, Philip L.S.M. Gordts, Sotirios Tsimikas
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