Lucio D’Anna: Can Inflammatory Biomarkers Identify Residual Risk in Atrial Fibrillation?
Lucio D’Anna, Consultant in Stroke Medicine at Imperial College NHS Trust, Honorary Senior Lecturer at Imperial College London, shared a post on X about a recent article he and his colleagues co-authored, published in Stroke, adding:
“Why do patients with atrial fibrillation continue to experience ischemic events despite anticoagulation?
Anticoagulation reduces thromboembolic risk, but residual risk remains.
Could inflammation help identify patients at higher risk?
Our new ASPERA-R study in Stroke.
In 671 patients across 14 centres, high inflammatory burden was associated with:
- 53% higher risk of ischemic events
- 70% higher mortality
- 2.2 times the odds of hemorrhagic transformation
- 2.9 times the hazard of major bleeding
Routine biomarkers may help identify residual risk.”
Title: Impact of Inflammatory Burden on Outcomes After Breakthrough Ischemic Stroke: Insights From the ASPERA-R Study
Authors: Lucio D’Anna, Gabriele Prandin, Federico De Santis, Francesca Gabriele, Raffaele Ornello, Angelo Cascio Rizzo, Maria Sessa, Ghil Schwarz, Rachele Tortorella, Leonardo Pantoni, Francesco Mele, Giuseppe Scopelliti, Ilaria Cova, Barbara Casolla, Monica Gulla, Souleymane-M-Bara Diallo, Marjolaine Baude, Laura González, Ricardo Rigual, Blanca Fuentes, Pietro Caliandro, Aurelia Zauli, Giuseppe Reale, Ahmed Abdelalim, Sandra Ahmed, Samah Ali Ismail, Liqun Zhang, Tara Latimer, Muhammad Elboghday, Federica Ferrari, Federico Mazzacane, Ana Catarina Fonseca, Bernardo Antunes, Maria Grazia Piscaglia, Giorgia Balducci, Ludovica Maria Miserocchi, Marialuisa Zedde, Ahmed Elsaid Elsayed, Gurav Desai, Muhammad Jaffar, Soma Banerjee, Alexandros Polymeris, Simona Sacco, Matteo Foschi
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