Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
August, 2026
August 2026
M T W T F S S
 12
3456789
10111213141516
17181920212223
24252627282930
31  
Bryan Fry: First Evidence That Bothrops atrox Venom Directly Activates Human Factor VII
environment.uq.edu.au
Feb 23, 2026, 17:42

Bryan Fry: First Evidence That Bothrops atrox Venom Directly Activates Human Factor VII

Bryan Fry, Professor of Toxicology at the University of Queensland, shared a post on LinkedIn, about a recent article he and his colleagues co-authored, adding:

”Highlights

  • Neonate Bothrops atrox venom is far more procoagulant than adult venom on plasma and fibrinogen.
  • Neonate venom activates prothrombin and Factor VII via FVa-dependent pathways more strongly than adults.
  • We provide the first evidence that Bothrops atrox venom directly activates human Factor VII.
  • Clinically used antivenoms neutralise adult venom better than neonate venom; Butantan performs best.
  • Findings indicate high coagulopathy risk after neonate bites and support adding neonate venom to antivenom immunizing mixture.”

Title: Pirates of the coagulase: Clinical implications of dramatic ontogenetic shifts in Yellow Beard (Bothrops atrox) lancehead pitviper Factor Va-mediated venom activation of blood clotting factors

Authors: Katherine Jordan, Patrick S. Champagne, Lorenzo Seneci, Bryan G. Fry

Read the Full Article on Toxicon.

Bryan Fry

Stay updated with Hemostasis Today.

Bothrops atrox Bryan Fry Clotting Activation coagulation Health Hematology Hemostasis Hemostasis Today Katherine Jordan Lorenzo Seneci Medicine Patrick S. Champagne Pitviper Venom thrombosis Toxicology Toxicon Yellow Beard
NewsFeed