Ney Carter Borges: Low-Carbohydrate and Low-Fat Diet Quality and CHD Risk
Ney Carter Borges, Member Cardiologist of Global Physician Association at Cleveland Clinic Florida, shared a post on LinkedIn:
“Low-Carbohydrate and Low-Fat Diet Quality and CHD Risk
Macronutrient Quality Determines Coronary Heart Disease Risk.
Study Population: 198,473 participants
Follow-up: 5,248,916 person-years
Incident CHD cases: 20,033
Low-Carbohydrate Diet (Highest vs Lowest Quintile)
Healthy LCD (HLCD):
- HR 0.85 (95% CI 0.82–0.89)
- 15% lower CHD risk
Unhealthy LCD (ULCD):
- HR 1.14 (95% CI 1.09–1.20)
- 14% higher CHD risk
Animal-based LCD (ALCD):
- HR 1.07 (95% CI 1.02–1.12)
Vegetable-based LCD (VLCD):
- HR 0.94 (95% CI 0.90–0.99)
Low-Fat Diet (Highest vs Lowest Quintile)
Healthy LFD (HLFD):
- HR 0.87 (95% CI 0.83–0.91)
- 13% lower CHD risk
Unhealthy LFD (ULFD):
- HR 1.12 (95% CI 1.07–1.17)
- 12% higher CHD risk
Vegetable-based LFD (VLFD):
- HR 0.87 (95% CI 0.83–0.91)
Metabolomic Correlates
Healthy LCD/LFD patterns were associated with:
- Decreased Triglycerides
- Increased HDL-C
- Decreased hs-CRP
- Increased 3-Indolepropionic acid
- Decreased Valine
Unhealthy patterns showed the opposite metabolic signature.”
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