Søren Hough: A Bispecific siRNA Design for Simultaneous Gene Silencing in Cancer
Søren Hough, Editor, Drug Modalities and TIDES Global at BioXconomy, shared a post on LinkedIn:
“Genetics is a lot more complicated than ‘turn off Gene A, get Disease B.’
Oftentimes, genetic networks look more like logic puzzles, requiring a sometimes dizzying combination of activation, silencing, modulating, and other tweaks to achieve a particular outcome.
That’s the logic researchers in Osaka, Japan, have applied to their ‘bispecific’ siRNA design: a single molecule that can shut off two genes at once. Their goal is to tackle diseases like cancer by finding consensus regions between genes with the goal of simultaneous gene silencing. Doing so could help bypass genetic redundancies that make some cancer types resistant to treatment.
Check out my story over at BioXconomy .”
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