Swati Bhayana/LinkedIn
May 7, 2026, 12:44
Swati Bhayana: Restless Leg Syndrome in Thalassemia Major
Swati Bhayana, Pediatric Oncologist, Consultant at Fortis Healthcare, shared a post on LinkedIn:
“Rusty leg syndrome in thalassemia major
Diverse cutaneous manifestations in thalassemia– seen in up to 90% patients:
- Skin type – Fitzpatrick skin type- 3, 4 or 5
- Bronze or slate-grey skin tone
- Freckles
- Xerosis cutis – with or without pruritis
- Rusty leg syndrome or hemosiderin depositions
- Pseudoxanthoma Elasticum (PXE)-Like Syndrome- oxidative stress and iron-mediated damage to elastic fibres- resembling ‘plucked chicken skin’
- Chronic Leg Ulcers: 8% of patients, chronic tissue hypoxia, iron overload, and venous insufficiency
- Cutaneous Small-Vessel Vasculitis (CSVV)
- Drug-related – Chelators related- Skin rashes and localised reactions at the injection site, such as induration, scarring, or urticaria or Hydroxyurea-related- Melanonychia (nail pigmentation), skin ulcers, and alopecia.”
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