Zain Khalpey: Left Atrial Appendage Closure vs Oral Anticoagulation in Atrial Fibrillation
Zain Khalpey, Adjunct Assistant Professor of Surgery at Columbia University Irving Medical Center, shared a post on LinkedIn about a recent article by Paschalis Karakasis, published in EP Europace, adding:
“Left Atrial Appendage Closure vs Oral Anticoagulation in Atrial Fibrillation.
A meta analysis of six randomized trials involving more than 7,000 patients compared left atrial appendage closure with oral anticoagulation for stroke prevention in atrial fibrillation.
LAAC was associated with fewer nonprocedural clinically relevant bleeding events, but a higher risk of ischemic stroke or systemic embolism.
There were no significant differences in overall stroke, major bleeding, hemorrhagic stroke, or mortality.
The findings suggest that LAAC should not be viewed as an equal replacement for anticoagulation in every patient.
Its role remains most relevant for carefully selected individuals who cannot tolerate long-term anticoagulation or have significant bleeding concerns.”
Title: Long-term efficacy and safety of left atrial appendage closure vs. oral anticoagulation in atrial fibrillation: a meta-analysis of randomized controlled trials
Authors: Paschalis Karakasis, Stylianos Tzeis, Athanasios Samaras, Konstantinos Vlachos, Konstantinos Pamporis, Panagiotis Theofilis, Apostolos Tzikas, Antonios P Antoniadis, Pierre Jaïs, Nikolaos Fragakis
Stay udpated on all scientific advances with Hemostasis Today.
-
Sep 18, 2026, 17:48Ronak H. Mistry: Updated ASH Guidelines Bring New Focus to Iron Deficiency
-
Sep 18, 2026, 17:32Hassan Kawtharany: New Ferritin Cutoffs for the Diagnosis of Iron Deficiency With or Without Anemia
-
Sep 18, 2026, 17:20Abhishek G P: GAVE as an Important Cause of Chronic Gastrointestinal Blood Loss
-
Sep 18, 2026, 17:08Irem Karaman Sebin: ASH 2026 Changes a Key Concept in Iron Deficiency
-
Sep 18, 2026, 16:51Adarsh Krishnan Sundara Rajan: Is VTE the Most Underdiagnosed Critical Threat in Modern Healthcare?
-
Sep 18, 2026, 16:19CRISPR and Hemophilia: The Next Frontier of In Vivo Gene Editing
-
Sep 18, 2026, 16:13Christian Irsara: PF4 Immunothrombosis Following Natural Adenovirus Infection
-
Sep 18, 2026, 16:10Leo Nicolai։ The Spleen Emerges as a Key Regulator of Thromboinflammation
-
Sep 18, 2026, 16:05Targeting Factor XI to Reduce Thrombosis Without Compromising Hemostasis – ISTH