Zia Ullah: RBC-Derived Extracellular Vesicles as Potential Biomarkers of Thrombotic Risk in Dengue
Zia Ullah, Ambassador at AxeUSCE, Bachelor of Medicine, Bachelor of Surgery at Saidu Medical College, shared a post on LinkedIn:
“An Emerging Research Question in Hematology.
What if red blood cell–derived extracellular vesicles (RBC-EVs) could help identify patients at higher risk of thrombosis in dengue infection?
RBC-EVs are increasingly recognized as biologically active particles involved in coagulation, inflammation, and thromboinflammation.
However, an important question remains:
Could RBC-EV levels or characteristics distinguish dengue patients who develop thrombotic complications from those who do not?
A prospective study comparing dengue patients with and without thrombosis could investigate RBC-EVs alongside platelet count, D-dimer, fibrinogen, PT/aPTT, and inflammatory markers.
Potential research direction:
Dengue – RBC-EV release – procoagulant activity – thrombotic complications.
This could help explore whether RBC-EVs have a future role as biomarkers of thrombotic risk in dengue.
Sometimes, the most interesting research questions are not about discovering something completely unknown—but about connecting two established biological pathways that have not yet been adequately studied together.”
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