Dec 2, 2025, 09:00
Signet Ring Cells Explained: Key Marker of Aggressive Gastric Carcinoma
Tareq Abadl, Medical Laboratory Specialist and Director of the Blood Bank at Dr. Abdelkader Al-Mutawakkil Hospital, posted on LinkedIn:
”Signet Ring Cell
A signet ring cell is a distinctive type of cell where the nucleus is pushed to the periphery by a large mucin-filled vacuole inside the cytoplasm.
This gives the cell the appearance of a signet ring, where the nucleus looks like the “seal,” and the clear cytoplasm forms the ring shape.
Microscopic Features
- Clear or pale cytoplasm due to mucin accumulation.
- Nucleus displaced to the periphery, compressed against the cell membrane.
- Ring-like shape, resembling a signet ring under the microscope.
Clinical Significance
- Signet Ring Cell Carcinoma (SRCC) – a malignant neoplasm marked by abundant signet ring cells.
- Most commonly associated with gastric carcinoma (stomach cancer).
- Can also appear in: Breast, Colon, Urinary bladder, Lung
Seen in other mucin-producing adenocarcinomas.
Key Point
Signet ring cell = a cell with mucin pushing the nucleus to one side, creating a ring-like appearance → a hallmark of gastric signet ring cell carcinoma.”
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