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Ghanim Ullah: Determining the Role of NCX1 in Neurons and Astrocytes During Ischemic Stroke
Ghanim Ullah/LinkedIn
Jun 7, 2026, 13:59

Ghanim Ullah: Determining the Role of NCX1 in Neurons and Astrocytes During Ischemic Stroke

Ghanim Ullah, Professor Of Physics at the University of South Florida, shared on LinkedIn about a recent article he and his colleagues co-authored, published in JCI Insight, adding:

”Our new study determines the cell type-specific role of the sodium-calcium exchanger (NCX1) in neurons and astrocytes during ischemic stroke — now published in JCI Insight!

During stroke, spreading depolarizations (SDs) — waves of near-complete ion gradient collapse — drive calcium overload and glutamate release, worsening brain injury.

NCX1 has been implicated in this process, but whether its role differs between neurons and astrocytes was unknown.

Using a mouse stroke model and computational modeling, we found that

  • Neuronal NCX1 plays a detrimental role in stroke by promoting SD susceptibility, calcium overload, and glutamate release.
  • Astrocytic NCX1 plays a protective role by limiting neuronal calcium accumulation and attenuating glutamate elevation.

These findings reveal that the same transporter can have fundamentally opposite consequences depending on cell type — an important consideration for NCX-targeted stroke therapies.

Congratulations to the whole team on this great work!”

Title: Neuronal and astrocytic sodium-calcium exchanger differentially regulates calcium and sodium overload during ischemic stroke

Authors: Somayyeh Hamzei Taj, Pawan Kumar Thapaliya, Cordula Rakers, Niklas J. Gerkau, Christine R. Rose, Ghanim Ullah, Gabor C. Petzold

Ghanim Ullah: Determining the Role of NCX1 in Neurons and Astrocytes During Ischemic Stroke

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Christine R. Rose Cordula Rakers Gabor C. Petzold Ghanim Ullah Health Hematology Hemostasis Hemostasis News Hemostasis Today Ischemic stroke JCI insight Medicine NCX1 Niklas J. Gerkau Pawan Kumar Thapaliya SDs Somayyeh Hamzei Taj spreading depolarizations thrombosis
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