Read Jamie Madrigal, Dougald Monroe, Suzanne Sindi and Karin Leiderman’s Latest Analysis on Emicizumab
Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:
”Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions
This study used mathematical modeling and biochemical assays to dissect how emicizumab, a bispecific antibody bridging activated factor IXa and factor X, functions differently from factor VIII.
It revealed that high emicizumab levels inhibit factor X activation via tissue factor pathway due to reduced lipid surface binding but enhance factor IXa-dependent activation of factor X on lipid surfaces.
The model provides kinetic estimates and explains emicizumab’s mechanism of enhancing coagulation through lipid-surface interactions.
Read this paper.
Authors: Jamie Madrigal, Dougald Monroe, Suzanne Sindi, Karin Leiderman”
Read the full article in JTH.
Article: Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions
Authors: Jamie Madrigal, Dougald Monroe, Suzanne Sindi, Karin Leiderman
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