Omid Seidizadeh: Evolutionary Constraint and Population Variation Across Coagulation Genes
Omid Seidizadeh, Research Leader of the A. Bianchi Bonomi Hemophilia and Thrombosis Center, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in RPTH Journal, adding:
“I am pleased to share our latest publication in the RPTH Journal on the Evolutionary constraint and population variation across coagulation genes.
Using genomic data from more than 800,000 individuals we investigated patterns of genetic variation across 34 genes involved in hemostasis.
Key findings:
- Hemostatic genes do not share a uniform pattern of genetic constraint.
- There are marked gene-specific differences in tolerance to potentially damaging variants.
- Pathogenic variants are consistently enriched at evolutionarily conserved sites across genes.
- These findings highlight the heterogeneous evolutionary pressures shaping the human hemostatic system.
Special thanks to Himani Chand, Andrea Cairo and Flora peyvandi”
Title: Evolutionary constraint and population variation across coagulation genes
Authors: Omid Seidizadeh, Himani Chand, Andrea Cairo, Flora Peyvandi
More posts featuring Omid Seidizadeh on Hemostasis Today.
-
Sep 25, 2026, 05:40Gerald Bertrand: Presenting UMi-NGS Non-Invasive Foetal HPA Genotyping at DGTI 2026
-
Sep 25, 2026, 05:33Urge Congress to support the Sickle Cell Disease Comprehensive Care Act – ASH
-
Sep 25, 2026, 05:24Isabelle Mahé: Reduced-Dose Apixaban in Extended CAT Treatment
-
Sep 25, 2026, 05:15Maria Cherska: High Cholesterol Isn’t Always Diet or Lifestyle – Sometimes It’s Genetic
-
Sep 25, 2026, 05:07Nancy Braithwaite: BBTS Specialist Certificate in Transfusion Science Practice
-
Sep 24, 2026, 18:43Hugh Nguyen: Honored to Accept the Friend of Singapore Red Cross Award
-
Sep 24, 2026, 18:42Titilope Fasipe: Proud to Support American Society of Hematology’s SCD Initiative
-
Sep 24, 2026, 18:34Ifeanyichukwu Ifechidere: Why Coagulation Samples Can Be “Too Valuable to Throw Away”?
-
Sep 24, 2026, 18:33Aswin K. Mohan: When a Superpower Hears the Call for Blood