Shadi Tabibian: Navigating Modern Diagnosis and Individualized Care in Hemophilia A and B
Shadi Tabibian, Deputy of research at Blood Diseases Research Centers in Iran University of Medical Sciences, shared a post on LinkedIn about a recent article by Ming Y. Lim et al, published in Journal of Thrombosis and Haemostasis, adding:
“Hemophilia A and B: From Diagnosis to Personalized Lifelong Care.
The management of hemophilia has evolved dramatically—from conventional factor replacement to extended half-life concentrates, FVIII mimetics, rebalancing agents, and gene therapy.
This recent educational review provides a comprehensive overview of:
- The genetic and pathophysiological basis of hemophilia A and B
- Clinical presentation and laboratory diagnosis
- The expanding treatment landscape
- Treatment monitoring and inhibitor management
- Hemophilic arthropathy and age-related comorbidities
- The essential role of multidisciplinary and personalized care
Despite major therapeutic advances, important challenges remain.
Inhibitor development, progressive joint disease, laboratory monitoring of novel therapies, equitable treatment access, and the growing burden of cardiovascular and other age-related conditions continue to shape clinical practice.
The key message is clear: modern hemophilia care must extend beyond bleeding control.
It should aim to preserve joint health, reduce treatment burden, improve quality of life, and support individuals with hemophilia throughout their lifespan.”
Title: Diagnosis and management of hemophilia A and B
Authors: Ming Y. Lim, Jesús Ardila, Giancarlo Castaman, Yesim Dargaud, Karin Fijnvandraat, Roberta Gualtierotti, Cedric Hermans, Susan Shapiro
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