Timothy Glidewell: Genetic Signals of Platelet and Clotting Pathways in Cryptogenic Stroke
Timothy Glidewell, Spatial Regional Account Manager at Bruker Spatial, shared on LinkedIn about a recent article by Priya Dev et al, published in Plos Journal:
”Cryptogenic stroke is one of the toughest problems in medicine: patients have a stroke, but we can’t pin down the ‘why.’
This study looks for genetic clues in an understudied Indian cohort.
Using whole-exome sequencing on 16 patients and 16 unaffected relatives, the authors found 17 rare, potentially harmful variants across 15 known stroke-related genes.
When they grouped the signals, a clear theme popped out: platelet and clotting biology (think platelet activation and fibrin clot formation).
They also highlighted a small network of interacting candidates for follow-up.
Next step: validating these pathways in tissue.
GeoMx could help map RNA/protein signals in specific vascular or clot regions.”
Title: Short report: Targeted analysis of whole exome sequencing data in Indian cryptogenic stroke patients
Authors: Priya Dev, Jenefer M. Blackwell, Rajiv Kumar, Vijay Mishra, Abhishek Pathak
Read the Full Article on Plos Journal
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 14, 2026, 13:04Mohammed M. Aboudeif: Cerebral Venous Thrombosis – Think Early, Treat Decisively
-
Aug 14, 2026, 12:49Ahmed Hawash: The Hawash Method for Managing Extreme ICU Complexity
-
Aug 14, 2026, 12:42Why Unfractionated Heparin Still Matters in Modern Anticoagulation – Thrombosis Canada
-
Aug 14, 2026, 11:40Liz Devlin: When HHT Affects More Than What We Can See
-
Aug 14, 2026, 11:29Archil Jaliashvili: Can Italy Reduce Its Dependence on Imported Plasma
-
Aug 14, 2026, 11:21Osama Alabdi: Never Ignore a Weak Reaction in the Blood Bank
-
Aug 14, 2026, 11:14Yohan Santin: How Lysosomal Dysfunction Drives Cardiac Aging
-
Aug 14, 2026, 11:06Nicolas Schommer: When Neutrophils Turn Metabolic Stress Into Organ Injury
-
Aug 14, 2026, 10:49Pablo Corral: Can One Infusion Lower LDL for Years