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Why Pediatric ROTEM Needs Race-Specific Reference Ranges?
Vera Ignjatović AM PhD EMBA GAICD OLY/LinkedIn
Nov 23, 2025, 14:43

Why Pediatric ROTEM Needs Race-Specific Reference Ranges?

Vera Ignjatovic, Founder and Managing Director of Ignis Innovations Pty Ltd, shared a post by Journal of Thrombosis and Haemostasis (JTH) on LinkedIn:

”Here is the link to our paper describing the age and race-specific association of fibrinogen and Rotational Thromboelastometry (ROTEM) parameters in a diverse pediatric population.

Inclusion of a diverse population in establishing race-specific pediatric RIs has clinical and public health relevance for a more accurate diagnosis and personalized treatment.

Thank you, Marium Malik, Maha Al-Ghafry, Maribel Lema, Vijay Nandi, Linda Shore-Lesserson, and Suchitra S. Acharya for making this study possible. I am privileged to have worked with you in the late stages of this study.”

Quoting Journal of Thrombosis and Haemostasis (JTH)’s post:

”Association of fibrinogen and ROTEM parameters with age and race in a diverse pediatric population: a single-center study

By Marium Malik, Maha Al-Ghafry, Maribel Lema, Vijay Nandi, Vera Ignjatović, Linda Shore-Lesserson, and Suchitra S. Acharya

• Pediatric reference ranges for Rotational Thromboelastometry (ROTEM) – a whole-blood coagulation assay – are limited and rarely account for racial diversity.
• In 105 racially diverse children (1–21 years), investigators analyzed how age and race affect fibrinogen and ROTEM variables (EXTEM, INTEM, and FIBTEM).
• Fibrinogen and FIBTEM clot strength increased with age. Among Black/African American participants, rising age correlated with shorter clot times and stronger clot firmness, suggesting a prothrombotic hemostatic profile. This underscores the need for race-specific pediatric reference intervals for personalized coagulation assessment.

Read the article here.”

Title: Association of fibrinogen and Rotational Thromboelastometry (ROTEM) parameters with age and race in a diverse pediatric population: a single-center study

Authors: Marium Malik, Maha Al-Ghafry, Maribel Lema, Vijay Nandi, Vera Ignjatovic, Linda Shore-Lesserson, Suchitra S. Acharya

ROTEM

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fibrinogen Health Hematology Hemostasis Hemostasis Today Ignis Innovations Pty Ltd JTH Linda Shore-Lesserson Maha Al-Ghafry Maribel Lema Marium Malik Medicine Pediatric Health Pediatric Hematology Pediatric Hemostasis Pediatric ROTEM Rotational Thromboelastometry ROTEM Suchitra S. Acharya thrombosis Vera Ignjatovic Vijay Nandi
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