Pascal Mensah/LinkedIn
Feb 6, 2026, 18:52
Pascal Mensah: Why Inflammation Loves Redox Entropy?
Pascal Mensah, Specialist in Immunology at Juaneda Hospitales, shared a post on LinkedIn:
“Why inflammation loves redox entropy?
When mitochondria can’t manage redox entropy:
- Electrons leak → ROS
- ROS act as danger signals
- NF-κB, inflammasomes activate
- Glycolysis replaces oxidative order
Immune activation is therefore:
A controlled increase in redox entropy used as a signalling strategy
Chronic inflammation = failure to restore redox order.
Redox entropy is the natural tendency of electrons to dissipate their free energy; mitochondria exist to slow, structure, and temporarily harness this dissipation to power endergonic life processes.
It allows you to say — rigorously:
- Mitochondrial disease is a redox coordination disorder
- Ageing is progressive redox entropy leakage
- Exercise is intentional redox stress that improves entropy handling
- Immunosenescence is the loss of redox control, not immune weakness. “
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