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Timo Siepmann: Does Stroke Origin Change How IV Thrombolysis Helps During Thrombectomy?
Timo Siepmann,Annahita Sedghi/LinkedIn
Mar 27, 2026, 17:24

Timo Siepmann: Does Stroke Origin Change How IV Thrombolysis Helps During Thrombectomy?

Timo Siepmann, Academic Director of Dresden International University (DIU), Consultant at Carl Gustav Carus University Hospital, shared on LinkedIn about a recent article he and his colleagues co-authored, adding:

”Does stroke origin change how IV thrombolysis helps during thrombectomy?

Our study, spearheaded by Dr. Annahita Sedghi, shows a divergence:

  • Non-cardioembolic stroke: IVT was associated with 40% faster reperfusion and 36% fewer aspiration attempts.
  • Cardioembolic stroke: If distal clot migration occurred, IVT was associated with a 43% lower likelihood of successful reperfusion during thrombectomy.

In conclusion, IVT facilitates clot removal in non-cardioembolic cases but may complicate things when cardioembolic clots migrate.”

Title: IV Thrombolysis Facilitates Interventional Reperfusion in Non-Cardioembolic but Not Cardioembolic Stroke

Authors: Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann

Read the Full Article on Annals of Clinical and Translational Neurology

Timo Siepmann: Does Stroke Origin Change How IV Thrombolysis Helps During Thrombectomy?

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Annahita Sedghi cardioembolic clots Daniel P O Kaiser Erik Simon Hagen B. Huttner Health Hematology Hemostasis Hemostasis News Hemostasis Today IVT Martin Arndt Medicine Norma J. Diel stroke Thrombectomy Thrombolysis thrombosis Timo Siepmann Volker Puetz Witold H. Polanski
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