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Heghine Khachatryan։ Targeting High Risk Antiphospholipid Syndrome in Pregnancy with Hydroxychloroquine
Heghine Khachatryan/LinkedIn
Apr 6, 2026, 16:26

Heghine Khachatryan։ Targeting High Risk Antiphospholipid Syndrome in Pregnancy with Hydroxychloroquine

Heghine Khachatryan, Editor-in-Chief of Hemostasis Today, Head of Hemophilia and Thrombosis Center at Yeolyan Hematology and Oncology Center, shared a post on Linkedin:

”Antiphospholipid Syndrome in Pregnancy: Is There a Role for Hydroxychloroquine?

In recent years, the management of obstetric antiphospholipid syndrome (APS) has evolved beyond conventional therapy.

While low-dose aspirin and LMWH remain the cornerstone, an important question emerges:

What should we do in refractory or high-risk APS?

Emerging evidence suggests:

Hydroxychloroquine (Plaquenil) exerts:

  • Anti-thrombotic effects
  • Modulation of aPL-mediated endothelial injury
  • Reduction of placental inflammation and microthrombosis

Clinical data indicate:

  • Improved live birth rates
  • Reduced pregnancy complications
    – particularly in refractory APS

Who may benefit most?

  • Triple-positive APS
  • Refractory obstetric APS
  • APS associated with SLE

Clinical positioning:

Hydroxychloroquine is not first-line, but:

  • A valuable adjunctive therapy
  • Considered in high-risk or treatment-resistant cases

Safety profile:

  • Well-established safety in pregnancy
  • No proven teratogenicity
  • Long-standing use in autoimmune diseases

Key message:
APS in pregnancy is not a uniform entity — it is a risk spectrum requiring precision medicine.

Hydroxychloroquine represents a strategic addition, not for all, but for those who need more than standard therapy.”

Heghine Khachatryan։ Targeting High Risk Antiphospholipid Syndrome in Pregnancy with Hydroxychloroquine

Other posts featuring Heghine Khachatryan on Hemostasis Today.

Antiphospholipid Syndrome APS Health Heghine Khachatryan Hematology Hemostasis Hemostasis News Hemostasis Today Hydroxychloroquine Medicine Pregnancy
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