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Philippe Guerci: HIT after Cardiac Surgery – Are We Using the Right Tools?
Philippe Guerci/X
May 4, 2026, 09:36

Philippe Guerci: HIT after Cardiac Surgery – Are We Using the Right Tools?

Philippe Guerci, Professor at CHRU de Nancy, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Journal of Cardiothoracic and Vascular Anesthesia, adding:

“New publication – HIT after cardiac surgery: are we using the right tools?

Work led by Thomas Klein, bringing together a highly talented team of hematobiologists (Philippe Savard, Toussaint Hacquard Marie, Emmanuel de Maistre, Thomas Lecompte), clinicians (Sandrine Grosjean, Guillaume Soyer) and methodologists-biostatisticians (Cedric Baumann, Amandine Luc, Elodie Jeanbert) across two expert centers.

Congratulations to all.

This bicentric study (Nancy 🇫🇷 and Dijon 🇫🇷) provides one of the most robust comparative evaluations to date of clinical scores for heparin-induced thrombocytopenia (HIT) in the challenging context of cardiac surgery with CPB.

Key findings:

  • No clear winner among the 4 major HIT scores (4Ts, HEP, CPB, GFHT)
  • All scores show excellent rule-out performance (NPV nearly 94–97%)
  • Limited positive predictive value – caution against overdiagnosis
  • Identification of a typical biphasic platelet pattern (early drop and delayed nadir nearly day 10) as a strong clinical signal
  • The HEP score trends toward best overall performance, but without statistical superiority

Clinical message:

  • In post-cardiac surgery patients, HIT scores are rule-out tools, not rule-in tools
  • Diagnostic strategies must remain multimodal, combining clinical expertise with advanced functional assays
  • This work highlights the strength of close collaboration between anesthesiologists, intensivists, and hematobiologists, essential to tackle complex perioperative coagulation disorders.

A great example of how bicenter collaboration enhances external validity and clinical relevance.”

Title: Evaluating Four HIT Prediction Scores After Cardiac Surgery With Cardiopulmonary Bypass: A Comparative Study

Authors: Guillaume Soyer, Philippe Savard, Philippe Guerci, Marie Toussaint Hacquard, Elodie Jeanbert, Amandine Luc, CĂ©dric Baumann, Sandrine Grosjean, Emmanuel de Maistre, Thomas Lecompte, Thomas Klein

Philippe Guerci

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Amandine Luc Cedric Baumann Elodie Jeanbert Emmanuel De Maistre Guillaume Soyer Health Hematology Hemostasis Hemostasis News Hemostasis Today heparin-induced thrombocytopenia HIT Medicine Philippe Guerci Philippe Savard Sandrine Grosjean Thomas Lecompte Toussaint Hacquard Marie
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