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Caitlin Raymond: How STOP-BABESIOSIS Just Rewrote 40 Years of Practice
Caitlin R./LinkedIn
May 6, 2026, 02:12

Caitlin Raymond: How STOP-BABESIOSIS Just Rewrote 40 Years of Practice

Caitlin Raymond, Assistant Professor of Pathology and Transfusion Medicine at University of Wisconsin-Madison, shared a post on LinkedIn:

“We’ve been performing RBC exchange for severe babesiosis since 1980.

Until 2026, the entire controlled evidence base for that practice was 28 patients.

The STOP-BABESIOSIS investigators just changed that.

  • 629 patients across 82 sites, 15 years of data
  • Sequential target trial emulation to minimize bias
  • Nearly 5-fold reduction in death or 30-day readmission with exchange (aOR 0.22, 95% CI 0.09–0.51)
  • Consistent across 8 sensitivity analyses

The caveats are real – residual confounding, small death count, readmissions driving most of the composite.

And an RCT is almost certainly never coming.

But for a procedure built on case reports and mechanistic logic for four decades, this is about as close to a definitive answer as we’re going to get.

New post breaks down the evidence – including where the O’Bryan 2021 Yale data fit in – for the overworked fellow trying to make sense of it.”

Caitlin Raymond

Other posts featuring Caitlin Raymond on Hemostasis Today.

Caitlin Raymond Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine STOP-BABESIOSIS
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