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Dirk Sibbing: Potent P2Y12 Inhibition in Patients With Atrial Fibrillation and Acute Coronary Syndrome
Dirk Sibbing,Konstantinos Rizas/LinkedIn
Sep 8, 2026, 08:50

Dirk Sibbing: Potent P2Y12 Inhibition in Patients With Atrial Fibrillation and Acute Coronary Syndrome

Dirk Sibbing, Cardiologist and Angiologist at Lauterbacher Mill Private Clinic and LMU Munich, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Nature Medicine, adding:

“EPIDAURUS Trial – presented at ESC 2026 and published simultaneously in nature medicine

DOAC plus potent P2Y12 inhibition vs. DOAC plus clopidogrel and in-hospital aspirin in ACS patients (n=602) with atrial fibrillation undergoing PCI

Treatment with a potent P2Y12 inhibitor was associated with higher bleeding rates without a clear reduction in the risk of ischemic complications

Key take: More potent platelet inhibition does not necessarily result in less ischemic events

Clinical scenarios differ in terms of assets and drawbacks of potent platelet inhibition with prasugrel or ticagrelor

Congratulations to Prof. Dr. med. Konstantinos Rizas and Prof. Dr. med. Steffen Massberg at Cardio LMU for the trial lead and for bringing together so many cardiologists for this multi-centre RCT

Please see our results published in Nature Medicine”

Title: Dual antithrombotic therapy using potent antiplatelet inhibitors in atrial fibrillation and acute coronary syndrome: a randomized controlled trial

Authors: Konstantinos D. Rizas, Konstantinos Mourouzis, Dominik Rath, Christoph B. Olivier, Laura Elisa Villegas Sierra, Theofanis Korovesis, Amin Polzin, Amani Al Tawil, Reza Wakili, Lukas von Stuelpnagel, Katharina Mayer, Marion Janisch, Tanja Ulrich, Sarah Lang, Sebastian K. G. Maier, Florian Brattinger, Lorenz Bott-Flügel, Harilaos Bogossian, Konstantinos Iliodromitis, Luisa Freyer, Julius Steffen, Konstantin Stark, Elodie Eiffener, Lauren E. Sams, Tobias Petzold, Axel Linke, Felix M. Heidrich, Samuel Sossala, Saif Zako, Nikolaos Dagkonakis, Andreas Schäfer, Frank Edelmann, David M. Leistner, Mariya Maslarska, Fabian Knebel, Georg Nickenig, Blerim Luani, Tienush Rassaf, Hüseyin Ince, Ibrahim Akin, Micha T. Maeder, Meinrad Gawaz, Hans-Josef Feistritzer, Norbert Frey, Stefan Kääb, Riza Sahin, Matthias Pauschinger, Thomas Stiermaier, Ingo Eitel, Marc Kollum, Jan Sebastian Wolter, Michael Schreinlechner, Axel Bauer, Christoph Stellbrink, Ulf Landmesser, Paulus Kirchhof, Dirk Sibbing, Holger Thiele, Adnan Kastrati, Ulrich Mansmann, Steffen Massberg
Dirk Sibbing: Potent P2Y12 Inhibition in Patients With Atrial Fibrillation and Acute Coronary Syndrome

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Acute coronary syndrome Adnan Kastrati Amani Al Tawil Amin Polzin Andreas Schäfer Antiplatelet Therapy antithrombotic therapy Atrial Fibrillation Axel Bauer Axel Linke Bleeding Risk Blerim Luani Cardiology Cardiovascular Research Christoph B. Olivier Christoph Stellbrink clinical trials clopidogrel David M Leistner Dirk Sibbing DOACs Dominik Rath Elodie Eiffener EPIDAURUS ESC 2026 Fabian Knebel Felix M. Heidrich Florian Brattinger Frank Edelmann Georg Nickenig Hans-Josef Feistritzer Harilaos Bogossian Hemostasis News Hemostasis Today Holger Thiele Hüseyin Ince Ibrahim Akin Ingo Eitel interventional cardiology Ischemic Events Jan Sebastian Wolter Julius Steffen Katharina Mayer Konstantin Stark Konstantinos D. Rizas Konstantinos Iliodromitis Konstantinos Mourouzis Laura Elisa Villegas Sierra Lauren E. Sams Lorenz Bott-Flügel Luisa Freyer Lukas von Stuelpnagel Marc Kollum Marion Janisch Mariya Maslarska Matthias Pauschinger Meinrad Gawaz Micha T. Maeder Michael Schreinlechner Nature Medicine Nikolaos Dagkonakis Norbert Frey P2Y12 Inhibitors Paulus Kirchhof PCI prasugrel randomized controlled trial Reza Wakili Riza Sahin Saif Zako Samuel Sossala Sarah Lang Sebastian K. G. Maier Stefan Kääb Steffen Massberg Tanja Ulrich Theofanis Korovesis Thomas Stiermaier ticagrelor Tienush Rassaf Tobias Petzold Ulf Landmesser Ulrich Mansmann
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