Limiaa Babikir: What Is Polyspecific DAT?
Limiaa Babikir, Medical Laboratory Technologist at King Abdulaziz Hospital for National Guard, shared a post on LinkedIn:
“Autoimmune hemolytic anemia (peripheral blood).
Spherocytes are commonly seen on the peripheral blood smear when extravascular immune hemolysis has occurred.
Serum Bilirubin (primarily indirect) and LD are usually elevated, and Urobilinogen may be increased in urine and stool specimens.
The DAT is usually positive.
The DAT (also called the direct antiglobulin test, and previously called the direct Coombs’ test) detects antibody and/or complement coating patient’s red cells.
In the DAT, patient red cells are washed to remove adherent proteins and then reacted with a reagent containing high-titer, polyspecific antibodies against both IgG (all subclasses) and complement, then examined for resulting red cell agglutination.
This is called the polyspecific DAT.”
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