Zoltan Nagy: Antibody Response Can Shift from Recognizing the Adenoviral Protein to Targeting PF4 in Rare VITT Cases
Zoltan Nagy, Emmy Noether Group Leader in Experimental Hematology at University Hospital Würzburg, shared a post on LinkedIn about a recent article by Jing Jing Wang et al., published in NEJM:
“Exceptional mechanistic study by Andreas Greinacher, Linda Schönborn and colleagues, delivered as stellar presentation at the Plenary Lecture of GTH2026, showing that in rare VITT cases a genetically predisposed and somatically mutated antibody response can shift from recognizing an adenoviral protein to targeting PF4.”
Title: Adenoviral Inciting Antigen and Somatic Hypermutation in VITT
Authors: Jing Jing Wang, Linda Schönborn, Theodore E. Warkentin, Luisa Müller, Thomas Thiele, Lena Ulm, Uwe Völker, Sabine Ameling, Sören Franzenburg, Lars Kaderali, Ana Tzvetkova, Alex Colella, Tim Chataway, Chee Wee Tan, Bridie Armour, Alexander Troelnikov, Lucy Rutten, James McCluskey, Roland Zahn, Tom P. Gordon, Andreas Greinacher
Read the Full Article on The New England Journal of Medicine
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