Multiplex Apolipoprotein Panel Boosts Cardiovascular Risk Prediction and Precision Therapy
Pablo Corral, Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, posted on LinkedIn:
”New in ATVB (Nov 2025)
Multiplex Apolipoprotein Panel Boosts Cardiovascular Risk Prediction and Precision Therapy
In >11,800 post-ACS patients from ODYSSEY OUTCOMES, a 9-plex mass-spectrometry apolipoprotein panel outperformed the standard lipid profile in predicting:
• Major adverse cardiovascular events (MACE) (AUC 0.65 vs 0.58)
• All-cause death (AUC 0.70 vs 0.60)
The panel also identified which patients benefit most from PCSK9 inhibition (alirocumab) – paving the way for precision lipidology.
Key components: Apo(a), ApoA-I, ApoA-II, ApoA-IV, ApoB, ApoC-I, ApoC-II, ApoC-III, ApoE.
Alirocumab reduced Apo(a), ApoB, and ApoC isoforms by >30–50%.
Bottom line:
Integrated apolipoprotein profiling refines risk stratification and optimizes treatment allocation – a step forward in personalized cardiovascular medicine.
Open Access”
Title: Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy
Authors: Esther Reijnders, Patrick M. Bossuyt, J. Wouter Jukema, L. Renee Ruhaak, Fred P.H.T.M. Romijn, Michael Szarek, Stella Trompet, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Sergio Fazio, Irena Stevanovic, Shaun G. Goodman, Robert A. Harrington, Harvey D. White, Philippe Gabriel Steg, Gregory G. Schwartz, Christa M. Cobb
Stay informed with Hemostasis Today.
-
Feb 23, 2026, 18:13Fight4Hematology Supports Research and Empowers the Next Generation – ASH
-
Feb 23, 2026, 17:59Wolfgang Miesbach: Real-World Evidence of Emicizumab on Joint Outcomes in Hemophilia A
-
Feb 23, 2026, 17:56Shiny K Kajal: The Transfusion Reaction We Often Miss
-
Feb 23, 2026, 17:53Radheshyam Meher: Contributing to the Transfusion Evidence Round-Up for International Childhood Cancer Day 2026
-
Feb 23, 2026, 17:46Mahesan Subramaniam: The Physiological Impact of Anger on Immunity
-
Feb 23, 2026, 17:42Bryan Fry: First Evidence That Bothrops atrox Venom Directly Activates Human Factor VII
-
Feb 23, 2026, 17:34Bastu Odoka: Why Blood Should NOT be Left at the Bedside to ‘Warm’
-
Feb 23, 2026, 17:28Henry Burkitt: Patients Are Challenging How the Medicines Policy System Works in England
-
Feb 23, 2026, 16:50Mutaz Al‑Sabah: Interesting Webinar on FH in Women is Now Available to Watch