Keisuke Goda: Real-Time and Image-Based Monitoring of Thrombosis During ECMO
Keisuke Goda, Professor at The University of Tokyo, and Adjunct Professor at University of California, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:
“Excited to share our new paper on real-time, image-based monitoring of thrombosis during ECMO.
ECMO can be life-saving for severe cardiac or respiratory failure—but intra-circuit thrombosis remains a major complication, occurring in up to ~35% of patients even with anticoagulation. Today’s monitoring often depends on visual inspection or indirect lab assays, which can miss early thrombus formation.
In this work, we introduce a direct, quantitative, real-time strategy: large-scale, image-based phenotyping of circulating platelets to track intra-circuit thrombogenesis during ECMO. Using an optofluidic time-stretch microscope (780 nm spatial resolution; >10,000 events/sec) and deep learning, we continuously tracked single platelets, platelet–platelet aggregates, and platelet–leukocyte aggregates.
Key findings:
- Circulating platelet aggregates rose significantly before pump exchange events (p = 0.0026), supporting their value as an early warning signal for intra-circuit thrombosis.
- The approach distinguished thrombosis from systemic inflammation (only platelet–leukocyte aggregates increased during inflammation).
- Aggregate levels correlated with lactate dehydrogenase (LDH), linking thrombosis signals to hemolysis or tissue injury.
Overall, our results show that high-throughput, image-based platelet phenotyping can provide a sensitive, real-time tool for ECMO monitoring—enabling earlier risk detection and helping guide optimized anticoagulant management.
If you’re working on ECMO, thrombosis, hematology, or high-throughput imaging/AI for clinical monitoring, I’d love to connect and discuss.”
Title: Early detection and real-time monitoring of thrombogenesis in extracorporeal circuits through large-scale image-based profiling of circulating platelets
Authors: Junyu Chen, Yuya Nobori, Yuqi Zhou, Minoru Ono, Jun Nakajima, Huidong Wang, Masaki Anrakuand Keisuke Goda
Read the Full Article on Journal of Physics: Photonics
More posts about Thrombosis.
-
Jun 27, 2026, 05:53Manuel Gutiérrez de Ravé: My Personal Takeaways from 39th International ISBT Annual Congress
-
Jun 27, 2026, 05:4710-Minute Paper-Strip Test Detects Factor VIII Inhibitors in Resource-Limited Settings – JTH
-
Jun 27, 2026, 05:23New episode – From Groundbreaking Therapies to the Ongoing Fight for Diagnosis – Global Hemophilia Report
-
Jun 27, 2026, 05:08Bethany Brown: Over 400 Ground EMS Agencies Now Carry Lifesaving Blood
-
Jun 27, 2026, 04:56Reza Shojaei: The Plasma Risk Governments Are Ignoring
-
Jun 27, 2026, 01:31Alessio De Rose: Addressing Micronutrient Deficiencies in the Era of GLP-1 Receptor Agonists
-
Jun 27, 2026, 01:21Michelle Sámano Sánchez: Exploring Vitamin C as an Adjunct Therapy for Anemia in Hemodialysis
-
Jun 27, 2026, 01:08Ana Raquel Gotine: The First Pragmatic Clinical Trial on MNPs and Childhood Anemia in Mozambique
-
Jun 27, 2026, 00:56Sherif Badawy: Reflecting on My Time with ASH CRTI