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Luca Saba on Carotid Artery Stenosis—An Impactful Bias in Ischemic Stroke Classification
Luca Saba/The Lancet
Nov 16, 2025, 23:28

Luca Saba on Carotid Artery Stenosis—An Impactful Bias in Ischemic Stroke Classification

Luca Saba, Dean of School of Medicine at the University of Cagliari, shared a post on LinekedIn:

”New publication in JAMA Cardiology

Together with Peter Libby, we explore a long-standing assumption in stroke medicine that may need revision.

For decades, carotid artery disease has been considered responsible for only a small fraction of ischemic strokes, typically those associated with high-grade stenosis.

This view shaped both clinical guidelines and epidemiologic data.

We argue that this framework introduces a systematic bias in how stroke risk is assessed and attributed.

A significant number of ischemic strokes may in fact originate from nonstenotic but biologically high-risk carotid plaques: lesions characterized by hemorrhage, inflammation, or surface ulceration, which traditional stenosis-based classifications fail to capture.

This conceptual bias affects not only clinical decision-making, potentially excluding at-risk patients from early intervention, but also epidemiologic estimates and public health planning, by underestimating the true contribution of carotid atherosclerosis to the global burden of stroke.

We propose that plaque-centered risk models, such as the recently introduced Carotid Plaque–RADS, can complement traditional stenosis thresholds by integrating compositional and morphological information from CT, MRI, and ultrasound.

This work calls for a shift from a purely geometric definition of disease to a biological and predictive model, one that better reflects the mechanisms underlying ischemic events and may improve prevention strategies worldwide.”

Read the full article here.

Article: Carotid Artery Stenosis—An Impactful Bias in Ischemic Stroke Classification

Authors: Luca Saba, Peter Libby

Luca Saba on Carotid Artery Stenosis—An Impactful Bias in Ischemic Stroke Classification

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carotid artery stenosis CT Health Hematology Hemostasis Hemostasis Today JAMA Cardiology Luca Saba Medicine MRI Peter Libby stroke thrombosis
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