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Wolfgang Miesbach: Comparing Clinician-Assessed and Patient-Reported Bleeding Scores and Quality of Life
Wolfgang Miesbach/LinkedIn
Feb 7, 2026, 16:43

Wolfgang Miesbach: Comparing Clinician-Assessed and Patient-Reported Bleeding Scores and Quality of Life

Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on LinkedIn about a recent article by Callie Berkowitz et al, published in RPTH Journal adding:

“Regardless of Diagnosis, Elevated BAT Scores Were Associated with Impairments in QoL.

This cross-sectional study from UNC Chapel Hill examined agreement between clinician-assessed and patient-reported bleeding tools and their relationship to quality of life in 101 adults referred for bleeding disorder evaluation:

The ISTH-BAT and Self-BAT showed strong agreement for menstrual bleeding (α=0.69) and postpartum hemorrhage (α=0.79), but less so for hemarthrosis and muscle hematoma-suggesting self-report works well for gynecologic bleeding domains.

Higher BAT scores correlated significantly with impaired quality of life across multiple domains: fatigue, social functioning, pain interference, sleep disturbance, and physical function.

Most striking: These QoL impairments were driven by bleeding severity (BAT scores) rather than laboratory findings. Patients in the highest ISTH-BAT tertile (scores ≥12) reported fatigue 1.4 SD worse than the US general population, along with pain and sleep disturbances 1.0 SD worse.

Comparable Quality-of-Life Burden Among BDUC and Confirmed Bleeding Disorders.

Patients with bleeding disorder of unknown cause (BDUC) experienced comparable QoL impairments to those with confirmed VWD or platelet defects. A 7-8 point BAT increase corresponded to 0.5 SD worse outcomes-a clinically meaningful effect.

Clinical Implications
Bleeding phenotype profoundly impacts patient wellbeing independent of hemostatic test results, and BAT scores may help identify who most needs comprehensive bleeding disorder care services-including the 45% diagnosed with BDUC.

Congratulations to Callie Berkowitz, Nigel Key and co-authors.”

Title: HTRS2025.P1.7 Quality of Life is Associated with ISTH-BAT Score, Similar between Bleeding Disorder of Unknown Cause and Other Mucocutaneous Bleeding Disorders

Authors: Callie Berkowitz, Supreet Goraya, Nigel Key, Alice Ma

Read the Full Article on RPTH Journal.

Wolfgang Miesbach: Comparing Clinician-Assessed and Patient-Reported Bleeding Scores and Quality of Life

Find more posts  featuring Wolfgang Miesbac on Hemostasis Today.

Alice Ma BAT Scores bleeding disorders Callie Berkowitz Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine Nigel Key Quality of Life RPTH Journal Supreet Goraya Wolfgang Miesbac
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