Amin Ullah/LinkedIn
Jun 3, 2026, 17:00
Amin Ullah: Presence of RBCs of Unequal Sizes in a Peripheral Blood Smear – Anisocytosis of RBC
Amin Ullah, Medical Laboratory Technician at Amaluna Medical Center, shared a post on LinkedIn:
“Anisocytosis of RBC –
Anisocytosis refers to the presence of red blood cells (RBCs) of unequal sizes in a peripheral blood smear.
It is commonly seen in various types of anemia and indicates abnormal erythropoiesis or RBC maturation.
Key Features:
- Increased variation in RBC size.
- Reflected by an increased RDW (Red Cell Distribution Width).
- May show microcytes, macrocytes, or a mixed population of RBCs.
- Best detected on a peripheral blood smear and automated hematology analyzers.
Common Causes:
- Iron deficiency anemia
- Megaloblastic anemia (Vitamin B12/Folate deficiency)
- Thalassemia
- Hemolytic anemia
- Liver disease
- Myelodysplastic syndromes (MDS)
- Post blood transfusion”
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