Krisstina Gowin: Could the Gut Microbiome Be the Missing Link in Hematology Outcomes?
Krisstina Gowin, Clinical Associate Professor at City of Hope, shared a post on LinkedIn:
“Could the gut microbiome be one of the most important—and most overlooked—factors influencing outcomes in hematology?
In our latest ASH Clinical News guest commentary, Dr. Urvi Shah and I explore the growing evidence that the gut microbiome plays a critical role in allogeneic stem cell transplantation and CAR T-cell therapy.
Emerging data suggest that microbial diversity, short-chain fatty acids, bile acid metabolism, dietary patterns, and even antibiotic exposure can influence treatment response, toxicity, graft-versus-host disease, and survival.
As hematologists, we meticulously optimize conditioning regimens, chemotherapy dosing, and supportive care. It may be time to bring microbiome health into that same conversation.
Key takeaways:
- Microbial diversity is associated with improved transplant outcomes.
- Fiber-rich, plant-forward dietary patterns support beneficial microbiome composition and metabolite production.
- Broad-spectrum anti-anaerobic antibiotics may adversely affect outcomes in both alloHCT and CAR T-cell therapy.
- The microbiome is emerging as a powerful biomarker and potential therapeutic target in hematology.
The future of hematology may not only depend on understanding the cancer and the immune system—but also the trillions of microbes that help shape both.
Thank you to my co-authors and collaborators, Dr. Urvi Shah, Dr. Jenny Paredes, and Dr. Marcel van den Brink, for advancing this exciting field.
Read the full article on ASH Clinical News.”
Stay updated with Hemostasis Today.
-
Jul 26, 2026, 01:48Rob Maloney: Why Global Diagnosis is the Missing Piece in Bleeding Disorder Care
-
Jul 26, 2026, 01:35Moustafa Abdou: Ehlers-Danlos Syndrome – Why Collagen Matters for Hemostasis
-
Jul 26, 2026, 01:25Vrisha Shah: Exploring Transgenic Mouse Models for Pregnancy Outcomes at ISTH 2026
-
Jul 26, 2026, 01:06Christine Bork: Why Misinformation Around a Single Vitamin Postpartum is Putting Babies at Risk
-
Jul 26, 2026, 00:44A Significant Step Forward For People With Bleeding Disorders In The Dominican Republic – WFH
-
Jul 25, 2026, 18:00The Evolving Landscape of Factor Replacement Therapy – EAHAD
-
Jul 25, 2026, 17:43Heghine Khachatryan: Advancing Care for Women and Girls With Hemophilia
-
Jul 25, 2026, 17:00Revathy R Menon: A Memorable Milestone at the 39th ISBT Congress
-
Jul 25, 2026, 16:19Nicola Potere: From Scientific Exchange to Global Collaboration at ISTH 2026