Sep 15, 2025, 08:42
W. Alberto Sifuentes Giraldo Highlights 4-Fold Higher Preeclampsia Risk in Pregnant SLE Patients with LN and APS
W. Alberto Sifuentes Giraldo, Rheumatologist at Hospital Nuestra Señora de Sonsoles (Sacyl), has shared a post on LinkedIn:
“Pregnant women with systemic lupus erythematosus (SLE) face a substantially higher risk of preeclampsia (PE) and PE with severity criteria, with both lupus nephritis (LN) and antiphospholipid syndrome (APS) emerging as strong, independent risk factors for these complications, as confirmed by a Spanish nation-wide cohort study:
- LN and APS nearly double PE risk beyond SLE by itself. Both conditions potentiate each other, since the combination of LN and APS results in a 4-fold higher risk of PE compared with SLE women without any of them.
- Renal involvement in SLE confers a high likelihood of developing PE, particularly in the more severe forms; LN independently triples PE with severity criteria odds.
These findings indicate that LN, and APS should be a fundamental factor in pre-conceptional planning, PE risk stratification, pregnancy monitoring, and prognostic assessment of PE in SLE patients.”
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