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Sam Tomy K.: Antinuclear Antibody Testing and Its Role in Autoimmune Disease Diagnosis
Sam Tomy K/ LinkedIn
Jun 5, 2026, 02:29

Sam Tomy K.: Antinuclear Antibody Testing and Its Role in Autoimmune Disease Diagnosis

Sam Tomy K, Laboratory Technician at MVR Cancer Centre and Research Institute, shared a post on LinkedIn:

“Understanding the ANA Test — A Key Marker in Autoimmune Diagnostics

The Antinuclear Antibody (ANA) test plays a crucial role in detecting autoimmune disorders such as lupus, Sjögren syndrome, systemic sclerosis, and mixed connective tissue disease.

In the laboratory, ANA testing by indirect immunofluorescence on HEp-2 cells remains the gold standard for identifying autoantibodies and interpreting fluorescence patterns.

Key highlights:

  • ANA patterns and their clinical significance
  • HEp-2 cell indirect immunofluorescence
  • Titer interpretation
  • Common autoimmune associations
  • Importance of quality control in ANA testing

As medical laboratory professionals, understanding the science behind ANA testing helps improve diagnostic accuracy and patient care.”

Sam Tomy K.: Antinuclear Antibody Testing and Its Role in Autoimmune Disease Diagnosis

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