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Caitlin Raymond: When We Talk About Plasma Exchange, Most Discussions Stop At What We’re Removing, But That’s Only Half The Story
Caitlin Raymond/LinkedIn
Oct 6, 2025, 03:44

Caitlin Raymond: When We Talk About Plasma Exchange, Most Discussions Stop At What We’re Removing, But That’s Only Half The Story

Caitlin Raymond, a board-certified Clinical Pathologist and current Transfusion Medicine Fellow at the National Institutes of Health, shared on LinkedIn:

”The Overlooked Half of the Exchange

When we talk about plasma exchange, most discussions stop at what we’re removing — antibodies, paraproteins, cytokines. But that’s only half the story.

Replacement fluid is the other half — and it quietly dictates safety, hemostasis, and recovery.

The right choice isn’t just technical; it’s clinical judgment in action.

In my latest blog post, I break down:

  • When to use albumin vs. plasma, and why the timing matters
  • How combination strategies (like 50:50 albumin–FFP) can balance practicality and bleeding risk
  • Common myths and misconceptions — including why “albumin is always safer” isn’t true
  • Real-world scenarios: TTP, transplant desensitization, AMR, and more

Read the full post.

Choosing the replacement fluid isn’t just following a protocol — it’s the art within the algorithm.

Because in apheresis, the machines may be automated, but judgment isn’t.”

Caitlin Raymond: When We Talk About Plasma Exchange, Most Discussions Stop At What We’re Removing, But That’s Only Half The Story

Stay tuned for more posts on transfusion medicine featured in Hemostasis Today.

Albumin Antibodies apheresis  Transfusion Medicine Caitlin Raymond cytokines FFP Health Hematology Hemostasis Hemostasis Today Medicine paraproteins Plasma Exchange thrombosis TTP
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