Mohamed Rawy: Clinical Pearls of Clopidogrel
Mohamed Rawy, Hospital Pharmacist at Specialized Medical Center Hospital, shared on LinkedIn:
”Clinical Pearls of Clopidogrel (Plavix®)
- Irreversible P2Y12 inhibitor antithrombotic
- Loading dose of 600mg has a more rapid and peak effect than doses of 300mg and thus it is preferred to be administered before PCI
Patients with Known to be poor CYP2C19 metabolizer will have reduced effect of clopidogrel and should use another P2Y12 inhibitor
- Avoid concomitant administration with PPI except Pantoprazole or Dexlansoprazole or Rabeprazole
Preferred over prasugrel and ticagrelor in patients with HBR or in case of thrombocytopenia
Check algorithm approved by ESC for switching between P2Y12 inhibitors (Do not combine together)
- Has many approved indications like IHD , IS , PAD , TAVI
Alternative to Aspirin in cases of Essential thromcythemia or Kawasaki disease or polycythemia vera
Can be used as a part of TAT for patients with ACS and AF
Duration of DAPT depends on Ischemic and Bleeding risks
Can be used for ACS patients who has thrombocytopenia up to a platelet count of 30.000 cell/mm3
It should be withhold before cardiac surgery by 1-5 days and by 5 days if non cardiac surgery and restart ASAP (≤24 hours) postoperative
- Bleeding can be reversed by administration of Desmopressin
Can be used during pregnancy or breastfeeding if ischemic event occurs
For full information kindly read the monograph (Drugs of ICU)”
Stay updated with Hemostasis Today.
-
Apr 14, 2026, 17:32Denise M.: Surviving Sepsis 2026 – The Upstream Revolution
-
Apr 14, 2026, 17:23Meghanath Yenni։ What’s New in Acute Ischemic Stroke in 2026
-
Apr 14, 2026, 17:11Phil Spinella: What Dose of TXA for Children With Severe Traumatic Bleeding Should You Use?
-
Apr 14, 2026, 17:08Abdulrahman Katib: How Endovascular Stenting Is Transforming the Treatment of Severe PTS
-
Apr 14, 2026, 17:00Anna A. Avagyan: Glad to Be Part of EHA Pediatric Hematology-Oncology Course
-
Apr 14, 2026, 16:58Ney Carter Borges: NLRP3 Inhibition in Atherosclerosis – Early Clinical Signal Beyond Lipids
-
Apr 14, 2026, 16:56Saskia Middeldorp: Key Takeaways from the 2026 ACC/AHA Guideline on Acute PE
-
Apr 14, 2026, 16:54Chokri Ben Lamine: Extracorporeal Photopheresis for aGVHD cGVHD Post-SCT – 50 Pearls
-
Apr 14, 2026, 16:49Ahmed Magdi Omar: Key Takeaways From the Latest 2026 Guidelines on Antiplatelet Therapy in AIS