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Mohamed Rawy: Clinical Pearls of Clopidogrel
Mohamed Rawy/LinkedIn
Feb 15, 2026, 06:45

Mohamed Rawy: Clinical Pearls of Clopidogrel

Mohamed Rawy, Hospital Pharmacist at Specialized Medical Center Hospital, shared on LinkedIn:

”Clinical Pearls of Clopidogrel (Plavix®)

  • Irreversible P2Y12 inhibitor antithrombotic
  • Loading dose of 600mg has a more rapid and peak effect than doses of 300mg and thus it is preferred to be administered before PCI

Patients with Known to be poor CYP2C19 metabolizer will have reduced effect of clopidogrel and should use another P2Y12 inhibitor

  • Avoid concomitant administration with PPI except Pantoprazole or Dexlansoprazole or Rabeprazole

Preferred over prasugrel and ticagrelor in patients with HBR or in case of thrombocytopenia

Check algorithm approved by ESC for switching between P2Y12 inhibitors (Do not combine together)

  • Has many approved indications like IHD , IS , PAD , TAVI

Alternative to Aspirin in cases of Essential thromcythemia or Kawasaki disease or polycythemia vera

Can be used as a part of TAT for patients with ACS and AF

Duration of DAPT depends on Ischemic and Bleeding risks

Can be used for ACS patients who has thrombocytopenia up to a platelet count of 30.000 cell/mm3

It should be withhold before cardiac surgery by 1-5 days and by 5 days if non cardiac surgery and restart ASAP (≤24 hours) postoperative

  • Bleeding can be reversed by administration of Desmopressin

Can be used during pregnancy or breastfeeding if ischemic event occurs

For full information kindly read the monograph (Drugs of ICU)”

Mohamed Rawy: Clinical Pearls of Clopidogrel

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Aspirin clopidogrel ESC Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine Mohamed Rawy P2Y12i Plavix PPI prasugrel thrombosis Ticagrelo
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