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Antiphospholipid Syndrome (APS) in Pregnancy – Key Takeaways
Sep 22, 2025, 06:33

Antiphospholipid Syndrome (APS) in Pregnancy – Key Takeaways

 

Dr. Mukesh, Assistant Professor of Clinical Immunology and Rheumatology at King George’s Medical University (KGMU), posted on X:

”Antiphospholipid Syndrome (APS) in Pregnancy – Key Takeaways

  •  APS affects 0.5% of the population but is a major cause of recurrent pregnancy loss (RPL), preeclampsia and FGR.
  • Pathogenesis: “Two-hit model” → aPL antibodies trigger endothelial/placental dysfunction → thrombosis + insufficiency.
  • Lupus anticoagulant (LA) = strongest predictor of poor outcomes.
  • Standard of care: Low-dose aspirin (LDA) + LMWH → boosts live birth rates.
  • Hydroxychloroquine (HCQ) reduces preterm birth and improves placental health in high-risk cases.
  • Refractory APS? → Novel options: TNF-α inhibitors, complement blockers (eculizumab), nitric oxide modulators, statins.
  • APS + SLE overlap = compounded risks → needs aggressive, multidisciplinary management.
  • CAPS (catastrophic APS) = rare but lethal; pregnancy can trigger it (mortality ~36%).
  • New 2023 ACR/EULAR criteria improve APS classification and risk stratification in pregnancy.

Bottom line: Early diagnosis, tailored therapy, and multidisciplinary care = better outcomes for mom and baby.”

Read the full review here.

Title: Antiphospholipid syndrome in pregnancy: a comprehensive literature review

Authors: Viorela Romina Murvai, Radu Galiș, Anca Panaitescu, Casandra Maria Radu, Timea Claudia Ghitea, Paula Trif, Miruna Onița-Avram, Alexandra Alina Vesa, Anca Huniadi

Antiphospholipid Syndrome (APS) in Pregnancy - Key Takeaways

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Alexandra Alina Vesa Anca Huniadi Anca Panaitescu Antiphospholipid Syndrome APS Aspirin BioMed Central BMC Casandra Maria Radu Catastrophic APS Health Hematology Hemostasis Hemostasis Today Heparin Hydroxychloroquine Immunology in Pregnancy King George's Medical University (KGMU) LMWH Low-Molecular-Weight Heparin Lupus anticoagulant (LA) Medicine Miruna Onița-Avram Mukesh Paula Trif Pregnancy Radu Galiș Recurrent Pregnancy Loss (RPL) Rheumatology thrombosis Timea Claudia Ghitea Viorela Romina Murvai
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