NewsFeed Voices Science Insight Innovation
September, 2025
September 2025
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
2930  
Antiphospholipid Syndrome (APS) in Pregnancy – Key Takeaways
Sep 22, 2025, 06:33

Antiphospholipid Syndrome (APS) in Pregnancy – Key Takeaways

 

Dr. Mukesh, Assistant Professor of Clinical Immunology and Rheumatology at King George’s Medical University (KGMU), posted on X:

”Antiphospholipid Syndrome (APS) in Pregnancy – Key Takeaways

  •  APS affects 0.5% of the population but is a major cause of recurrent pregnancy loss (RPL), preeclampsia and FGR.
  • Pathogenesis: “Two-hit model” → aPL antibodies trigger endothelial/placental dysfunction → thrombosis + insufficiency.
  • Lupus anticoagulant (LA) = strongest predictor of poor outcomes.
  • Standard of care: Low-dose aspirin (LDA) + LMWH → boosts live birth rates.
  • Hydroxychloroquine (HCQ) reduces preterm birth and improves placental health in high-risk cases.
  • Refractory APS? → Novel options: TNF-α inhibitors, complement blockers (eculizumab), nitric oxide modulators, statins.
  • APS + SLE overlap = compounded risks → needs aggressive, multidisciplinary management.
  • CAPS (catastrophic APS) = rare but lethal; pregnancy can trigger it (mortality ~36%).
  • New 2023 ACR/EULAR criteria improve APS classification and risk stratification in pregnancy.

Bottom line: Early diagnosis, tailored therapy, and multidisciplinary care = better outcomes for mom and baby.”

Read the full review here.

Title: Antiphospholipid syndrome in pregnancy: a comprehensive literature review

Authors: Viorela Romina Murvai, Radu Galiș, Anca Panaitescu, Casandra Maria Radu, Timea Claudia Ghitea, Paula Trif, Miruna Onița-Avram, Alexandra Alina Vesa, Anca Huniadi

Antiphospholipid Syndrome (APS) in Pregnancy - Key Takeaways

Stay updated with Hemostasis Today.

 

Alexandra Alina Vesa Anca Huniadi Anca Panaitescu Antiphospholipid Syndrome APS Aspirin BioMed Central BMC Casandra Maria Radu Catastrophic APS Health Hematology Hemostasis Hemostasis Today Heparin Hydroxychloroquine Immunology in Pregnancy King George's Medical University (KGMU) LMWH Low-Molecular-Weight Heparin Lupus anticoagulant (LA) Medicine Miruna Onița-Avram Mukesh Paula Trif Pregnancy Radu Galiș Recurrent Pregnancy Loss (RPL) Rheumatology thrombosis Timea Claudia Ghitea Viorela Romina Murvai
Insight
Science
Innovation
Voices
Insight
Sep 29, 2025, 12:54
Microfluidic Technology Uncovers Ongoing TTP Disease Activity
Insight
Sep 29, 2025, 12:43
Advancing Thrombosis Research: MRI-Based Methodology for Studying Thrombus Resolution
Science
Sep 29, 2025, 12:33
Allison Wheeler: Some Days I Love Science a Little Bit More
Voices
Sep 29, 2025, 07:02
Kambua Manundu: We Walked to Protest the Countless Lives of Women We Have Lost to Post Partum Hemorrhage
Voices
Sep 29, 2025, 06:41
Ouma Oluga Unveiled Plans to Make Sickle Cell Screening Mandatory in Kenya at 80th UN General Assembly
Science
Sep 29, 2025, 06:23
Yudi Hardianto and Colleagues Give a Review on Stroke Rehabilitation in LMICs
Insight
Sep 29, 2025, 05:58
Samwel Mikaye on Understanding, Diagnosing, and Managing Deep Venous Thrombosis (DVT)
Innovation
Sep 29, 2025, 05:06
Sue Bacon on the Importance of Addressing Hospital-Acquired DVT and PE
Voices
Sep 29, 2025, 04:51
Nathan Connell on Breakthrough Gene Therapy Advancing Care for People with Hemophilia
Science
Sep 29, 2025, 04:42
Wolfgang Miesbach on the Bi8 Study: A Novel FVIII-Mimetic Antibody Gene Therapy for Haemophilia A
Voices
Sep 29, 2025, 04:28
Emmeran Hauser: Fantastic to See First Results of Our Work in Europe
Science
Sep 29, 2025, 04:16
Salvador Payán Pernía on Equity Challenges in Access to Gene Therapy for Hemoglobinopathies