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Paul Bolaji: ACTIVATE Study in Ghana Demonstrates Over 400% Increase in Stroke Thrombolysis
Paul Bolaji, Priscilla Abrafi Opare-Addo/LinkedIn
May 28, 2026, 16:03

Paul Bolaji: ACTIVATE Study in Ghana Demonstrates Over 400% Increase in Stroke Thrombolysis

Paul Bolaji, Education Lead (Stroke Services) at Dorset County Hospital NHS Foundation Trust, shared on LinkedIn about a recent article by Priscilla Abrafi Opare-Addo et al, published in Journal of Stroke and Cerebrovascular Diseases, adding:

”Intentional. Innovative. Introspective.

A phenomenal piece of implementation research by Dr Priscilla Abrafi Opare-Addo and team from Ghana demonstrating that acute stroke reperfusion therapies can indeed be improved in Low- and Middle-Income Countries when context-specific barriers are intentionally addressed.

Their ACTIVATE study achieved more than a 400% increase in thrombolysis rates in a tertiary hospital through a multipronged implementation strategy focused on:

  • Stroke awareness campaigns
  • Protocolised stroke interventions
  • Multidisciplinary stroke teamwork
  • Financial mitigation strategies
  • Streamlined acute stroke pathways

Importantly, this was not merely a clinical intervention study it was implementation science in action: identifying contextual bottlenecks, understanding local realities, and designing pragmatic solutions tailored to the environment.

What stands out is the powerful message that improving acute reperfusion therapy in LMICs is not impossible.

  • The barriers are real
  • Delayed presentation,
  • Limited imaging access,
  • Workforce constraints,
  • Financial toxicity,
  • Fragmented pathways

but they are not insurmountable when tackled systematically.

Kudos to Dr Priscilla Abrafi Opare-Addo and the entire multidisciplinary team.

The hard work, systems thinking, and persistence behind this achievement truly show that this the kind of context-fit innovation and implementation research that Africa and indeed the wider LMIC community needs more of.”

Title: Integrating thrombolysis into routine stroke care in a Ghanaian tertiary hospital, using the implementation research logic model (IRLM) as a guiding framework

Authors: Priscilla Abrafi Opare-Addo, Fred Stephen Sarfo, Chris Oppong, Sheila Adamu, Ishaak Ahmed Yussif, Manolo Agbenorku, Kwasi Ankomah, Kwasi Adjepong Twum, Emmanuel Boadi Attafuah, Akosua Afriyie-Ansah, John Emmanuel Oppong Mensah, Sommik Miilon Duut, Minas Aikins, Alfred Opata, Benedict Kusi Ampofo, Yaa Bema Sarkodie Amankwah, Khabib Abdulai Baba, Serwaa Asare-Bediako, Eno Akua Afriyie Biney, Rexford Adu Gyamfi, José Biller

Paul Bolaji: ACTIVATE Study in Ghana Demonstrates Over 400% Increase in Stroke Thrombolysis

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ACTIVATE Akosua Afriyie-Ansah Alfred Opata Benedict Kusi Ampofo Chris Oppong Emmanuel Boadi Attafuah Eno Akua Afriyie Biney Fred Stephen Sarfo Ghana Health Hematology Hemostasis Hemostasis News Hemostasis Today Ishaak Ahmed Yussif John Emmanuel Oppong Mensah José Biller Journal of Stroke and Cerebrovascular Diseases Khabib Abdulai Baba Kwasi Adjepong Twum Kwasi Ankomah LMICs Manolo Agbenorku Medicine Minas Aikins Paul Bolaji Priscilla Abrafi Opare-Addo Rexford Adu Gyamfi Serwaa Asare-Bediako Sheila Adamu Sommik Miilon Duut Thrombolysis thrombosis Yaa Bema Sarkodie Amankwah
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