Haemophilia and Hereditary Angioedema – A Shared Therapeutic Revolution in Rare Diseases – RPTH Journal
RPTH Journal shared a post on LinkedIn about a recent article by Massimo Cugno et al., adding:
“Haemophilia and hereditary angioedema: two rare diseases, one shared therapeutic revolution
Haemophilia and hereditary angioedema (HAE) are both rare monogenic disorders involving dysregulation of serine protease pathways, blood coagulation and the kallikrein–kinin system, respectively.
Their clinical manifestations could not be more different: bleeding vs angioedema.
Yet their therapeutic journeys have evolved in strikingly parallel ways.
A new review Massimo Cugno and Pier Mannuccio Mannucci in RPTH Journal traces this parallel evolution, from plasma-derived products in the 1970s to the cutting edge of gene and RNA-based therapies today.
The therapeutic trajectories of haemophilia and HAE illustrate a broader principle: deep mechanistic understanding of rare diseases can drive the transition from managing acute episodes to achieving long-term disease control, and ultimately, cures.”
Title: Hemophilia and hereditary angioedema: parallel therapeutic advances in genetic diseases of serine protease pathways
Authors: Massimo Cugno, Pier Mannuccio Mannucci
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 21, 2026, 17:55Gayatri Kotwal։ New Review on Anemia, Pain, and Nutritional Deficiencies in Cancer Patients
-
Oct 21, 2026, 17:40Tetsuzan Ron: Iron Deficiency Without Anemia Clinical Impact and Management
-
Oct 21, 2026, 17:29Amir Hossien Esfandiari։ The Association Between Viral Infections and Aplastic Anemia
-
Oct 21, 2026, 17:16Melissa Hollo: A Meaningful Step Forward for Women’s Health
-
Oct 21, 2026, 17:09Chipili Ng’onga: Have You Ever Seen a Result That Just Didn’t Make Sense?
-
Oct 21, 2026, 16:57Fabrice Cognasse: Celebrating the Next Generation of Platelet Research and Transfusion Medicine
-
Oct 21, 2026, 16:47Christabel Odeta: Treating Pediatric Cancer in Children With Sickle Cell Disease
-
Oct 21, 2026, 16:36Sharlene Haywood: Bringing Multidisciplinary Learning Into Nursing Practice
-
Oct 21, 2026, 16:19Vanessa Carvalho: New Research on Platelet-Derived Extracellular Vesicles in Preeclampsia