Apixaban for Extended Treatment of Provoked VTE: New NEJM Study Challenges Treatment Paradigm
Emma P. with Clinical Research Professionals shared a post on LinkedIn:
“Apixaban for Extended Treatment of Provoked Venous Thromboembolism
A recent publication in The New England Journal of Medicine explores the benefits of continuing anticoagulation therapy with apixaban in patients who experienced venous thromboembolism (VTE) due to transient provoking factors like surgery, trauma, or immobility. Traditionally, these patients receive short-term anticoagulation, but this study challenges that paradigm.
Title: Apixaban for Extended Treatment of Provoked Venous Thromboembolism
Authors: Gregory Piazza, Behnood Bikdeli, Arvind K. Pandey, Darsiya Krishnathasan, Candrika D. Khairani, Antoine Bejjani, Ruth H. Morrison, Heather Hogan, Sina Rashedi, Mariana Pfeferman, Junyang Lou, John Fanikos, Nicole Porio, Lisa Rosenbaum, Piotr Sobieszczyk, Zhou Lan, Marie Gerhard-Herman, Umberto Campia, Samuel Z. Goldhaber
* Study Design:
Researchers conducted a randomized, double-blind trial comparing extended apixaban therapy to placebo in patients with provoked VTE who had completed initial anticoagulation. The goal: assess whether continued treatment could prevent recurrence without increasing bleeding risk.
* Key Findings:
• Apixaban reduced recurrent VTE by 82% compared to placebo.
• Major bleeding rates were low and comparable between groups.
• The benefit was consistent across subgroups, including those with persistent risk factors like obesity or cancer history.
* Clinical Implications:
This study suggests that extended apixaban therapy may be appropriate for select patients with provoked VTE, especially when enduring risk factors exist. It calls for a more individualized approach to anticoagulation duration—balancing recurrence risk with bleeding concerns.
* Why It Matters:
VTE remains a leading cause of preventable hospital death. This research could reshape guidelines and improve long-term outcomes for thousands of patients annually.
For clinicians, researchers, and policy-makers: this is a pivotal moment to re-evaluate how we define “provoked” VTE and tailor treatment accordingly.
Clinical and Research Focus
Broader Impact and Engagement.”
Stay updated with Hemostasis Today.
-
Jan 14, 2026, 16:22Leo Nicolai and Rainer Kaiser Link Procoagulant Platelets and Thromboinflammation in CVD
-
Jan 14, 2026, 16:01Renato Simonetti Presents a Pilot Project on AI-assisted Duplex Sonography for ICH
-
Jan 14, 2026, 15:47An Unusual Case from Mohammed Ameen: Unexpected Clot Unmasking Antithrombin III Deficiency
-
Jan 14, 2026, 11:38Khokon Miah Akanda Shares A major 4-Guideline Comparison on BP Management in Stroke
-
Jan 14, 2026, 11:26Pablo Albasanz-García and Colleagues on Anticancer Treatment-Induced Arterial and Venous Thrombosis
-
Jan 14, 2026, 11:16ISTH 2026: Laurent Bertoletti To Serve as Vice Theme Leader for VTE
-
Jan 14, 2026, 11:08Leni von Bonsdorff Invites You to Hear and Learn The Latest News in The Plasma Field
-
Jan 14, 2026, 05:56Arun V J on The “Whole Blood” Nostalgia Trap
-
Jan 13, 2026, 16:38Caitlin Raymond: Understanding TAMOF as a TTP-Like Process