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Abeer Alanazi: New Stroke Prevention Without Increased Bleeding Risk
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Apr 18, 2026, 14:31

Abeer Alanazi: New Stroke Prevention Without Increased Bleeding Risk

Abeer Alanazi, Senior Clinical Pharmacist at King Fahad Specialist Hospital Dammam, Member of European Stroke Organisation (ESO), shared a post on LinkedIn about a recent article by Mukul Sharma et al. published in NEJM, adding:

“Here’s the biggest thing to happen to secondary stroke prevention since the advent of clopidogrel!!

The phase 3 OCEANIC-STROKE trial

In patients with recent noncardioembolic ischemic stroke or high-risk TIA, asundexian 50 mg and antiplatelet therapy reduced the risk of ischemic stroke vs placebo (6.2% vs 8.4%; HR 0.74; P<0.001)

No increase in major bleeding.”

Title: Asundexian for Secondary Stroke Prevention

Authors: Mukul Sharma, Qiang Dong, Teruyuki Hirano, Scott E. Kasner, Jeffrey L. Saver, Jaime Masjuan, Andrew M. Demchuk, Charlotte Cordonnier, Daniel Bereczki, Georgios Tsivgoulis, Roland Veltkamp, Ivan Staikov, Hee-Joon Bae, Bruce C.V. Campbell, Andrea Zini, I-Hui Lee, Martin Kovar, Robert Mikulik, Robin Lemmens, José M. Ferro, Thompson Robinson, Hanne Christensen, Serefnur Ozturk, Ronen R. Leker, Peter Turcani, Agnieszka Slowik, Pablo Amaya, Fan Kee Hoo, Gian Marco De Marchis, Michael Knoflach, P.N. Sylaja, Jukka Putaala, Jonathan M. Coutinho, H. Bart van der Worp, Evija Miglane, Vaidas Matijošaitis, Arne G. Lindgren, Gisele Sampaio Silva, Else Charlotte Sandset, Saule T. Turuspekova, Pierre Amarenco, Kevin N. Sheth, Eric E. Smith, John W. Eikelboom, Raed A. Joundi, Karleen Schulze, Lizhen Xu, Laura Heenan, Pablo Colorado, Lars Keller, Eva Muehlhofer, Christoph Neumann, Hardi Mundl, Ashkan Shoamanesh

Abeer Alanazi: New Stroke Prevention Without Increased Bleeding Risk

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Abeer Alanazi Agnieszka Slowik Andrea Zini Andrew M. Demchuk Arne G. Lindgren Ashkan Shoamanesh Bruce C. V. Campbell Charlotte Cordonnier Christoph Neumann clopidogrel Daniel Bereczki Else Charlotte Sandset Eric E. Smith Eva Muehlhofer Evija Miglane Fan Kee Hoo Georgios Tsivgoulis Gian Marco De Marchis Gisele Sampaio Silva H. Bart van der Worp Hanne Christensen Hardi Mundl Health Hee-Joon Bae Hematology Hemostasis Hemostasis News Hemostasis Today I-Hui Lee Ivan Staikov Jaime Masjuan Jeffrey L. Saver John W. Eikelboom Jonathan M. Coutinho José M. Ferro Jukka Putaala Karleen Schulze Kevin N Sheth Lars Keller Laura Heenan Lizhen Xu Martin Kovar Medicine Michael Knoflach Mukul Sharma NEJM OCEANIC-STROKE trial P.N. Sylaja Pablo Amaya Pablo Colorado Peter Turcani Pierre Amarenco Qiang Dong Raed A. Joundi Robert Mikulik Robin Lemmens Roland Veltkamp Ronen R. Leker Saule T. Turuspekova Scott E. Kasner Serefnur Ozturk Teruyuki Hirano Thompson Robinson thrombosis Vaidas Matijošaitis
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