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Abhilasha Singh: Lp(a) as a Long-Term Cardiovascular Risk Signal in Healthy Women
Abhilasha Singh/LinkedIn
Mar 4, 2026, 13:50

Abhilasha Singh: Lp(a) as a Long-Term Cardiovascular Risk Signal in Healthy Women

Abhilasha Singh, Review Editor at Frontiers in Stroke and Reviewer at Springer Nature Phytomedicine, shared on LinkedIn about a recent article by Ask Tybjærg Nordestgaard and et al, published in JAMA Cardiology:

“Lp(a): A 30-Year Cardiovascular Risk Signal We May Be Underestimating

A 30-year follow-up of ~27,000 initially healthy women (JAMA Cardiology, 2026) shows that elevated Lipoprotein(a) [Lp(a)] independently predicts long-term cardiovascular risk.

What the Data Show

  • Lp(a) level of 30 mg/dL or higher is associated with an increased incidence of major adverse cardiovascular events.
  • Lp(a) levels of 120 mg/dL or higher increase the risk of coronary heart disease, ischemic stroke, and cardiovascular death.
  • Clear dose–response gradient
  • Risk persists beyond traditional factors
  • Lp(a) is largely genetically determined

Why This Matters Clinically

  • Prevention remains centered on LDL-C
  • Most 10-year risk models do not integrate Lp(a)
  • ‘Normal cholesterol’ does not equal absence of inherited risk.
  • Short-term prediction may miss lifelong exposure

Perspective

This study invites reconsideration of how we define and operationalize cardiovascular risk in the era of genomic medicine. ”

Title: Thirty-Year Risk of Cardiovascular Disease Among Healthy Women According to Clinical Thresholds of Lipoprotein(a)

Authors: Tybjærg Nordestgaard, Daniel I. Chasman, Vinayaga Moorthy, Jordan M. Kraaijenhof, Nancy R. Cook, I-Min Lee, Julie E. Buring, Paul M. Ridker

Read the Full Article on JAMA Cardiology .

Abhilasha Singh: Lp(a) as a Long-Term Cardiovascular Risk Signal in Healthy Women

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Abhilasha Singh Ask Tybjærg Nordestgaard Cardiology Cardiovascular Cardiovascular AI Daniel I. Chasman Hemostasis Today I-Min Lee Jordan M. Kraaijenhof Julie E Buring Nancy R. Cook Paul M Ridker Tybjærg Nordestgaard Vinayaga Moorthy
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