Alan Nurden: Highlighting the Role of Activated Platelets in Heart and Kidney Complications of Diabetes
Alan Nurden, Emeritus Research Director at CNRS, Co-Founder of the French National Reference Centre for Inherited Platelet Disorders (CRPP), shared a post on LinkedIn about a recent article by Nicolas Schommer et al, published in European Heart Journal:
“The mechanisms behind heart disease and kidney failure in patients with advanced stages of type I and type II diabetes remain incompletely defined. In this remarkable study, Schommer et al highlight roles for PAD4, neutrophil extracellular traps and inflammasome activation in these potentially fatal events.
The accumulation of platelets at sites of heart and kidney lesions is important not only for thrombosis but also as a source of the TGF-beta1 that drives renal fibrosis.
Whether activated platelets with surface expression of P-selectin and/or phosphatidylserine exposure (favoring thrombin generation) also help recruit neutrophils at the lesion sites also merits attention.
While recognizing past studies, the role of activated and procoagulant platelets (and derived microparticles) in diabetes merits further study.”
Title: Neutrophil extracellular traps and peptidylarginine deiminase 4–mediated inflammasome activation link diabetes to cardiorenal injury and heart failure
Authors: Nicolas Schommer, Nicolas Gendron, Krystin Krauel, Stijn Van Bruggen, Pierre-André Jarrot, Alexander Maier, William Chan, Harald F Langer, Daniel Duerschmied, Dirk Westermann, Karin Klingel, Denisa D Wagner, Lukas A Heger
Read the Full Article on European Heart Journal.
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