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New Study Finds Apixaban Safe for Stroke Prevention During Ramadan Fasting (API-RAM Trial)
Oct 8, 2025, 12:51

New Study Finds Apixaban Safe for Stroke Prevention During Ramadan Fasting (API-RAM Trial)

 

Ghada D. Mustafa, Cardiologist at Royal Brompton & Harefield Hospitals Specialist Care, shared a post by Leila Abid  on LinkedIn:

”A truly valuable and timely study addressing a real clinical question that many of us encounter in practice , anticoagulation management during Ramadan fasting.

The API-RAM study, led by Prof. Leila Abid and colleagues in Tunisia, provides important evidence supporting the safety and efficacy of apixaban during fasting among patients with atrial   fibrillation.

This work highlights the growing need for data that reflect our patients’ lived experiences and cultural contexts. Clinical recommendations must not only be evidence-based but also culturally   relevant.

Congratulations to the authors on advancing region-specific cardiovascular research that bridges science and patient reality.”

Quoting Leila Abid‘s post:

”We are pleased to share our recent publication: “Safety and effectiveness of apixaban use for stroke prevention during Ramadan fasting (the API-RAM study)”, conducted in Tunisia by the   cardiology department of Hedi Chaker university hospital of Sfax Led by Pr Leila Abid in collaboration with Pr. Faouzi Addad, PrSalem Abdessalem, Pr Ismail El Alamy and colleagues.
Key findings:
Among 257 patients included over two Ramadan seasons, no ischemic (stroke) events were reported
Apixaban, despite a twice-daily schedule, seems to maintain both safety and efficacy in this special setting. This gives support to clinicians advising patients with atrial fibrillation who wish to  fast.”

Read the full article here.

Title: Safety and effectiveness of apixaban use for stroke prevention during Ramadan fasting (the API-RAM study)

Authors: Aiman Ghrab, Rania Gargouri, Faouzi Addad, Anis Cheikhrouhou, Mariem Jabeur, Selma Charfeddine, Amine Bahloul, Zied Triki, Tarek Ellouze, Omar Abidi, Souad Mallek, Faten Triki, Salem Abdessalem, Ismail Elalamy, Leila Abid

Apixaban

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